How many employees work at Upstream Bio?
Upstream Bio, Inc. (UPB) has approximately 77 total employees worldwide as of March 2026, according to Revelio Labs workforce intelligence data. Upstream Bio’s total headcount has grown 124.4% from 34 employees in 2023 to 77 in 2026.
Is Upstream Bio hiring right now?
Yes, Upstream Bio is actively hiring. Upstream Bio had 4 active job postings in 2026, a 40.0% decline from 2025 — see job openings & hiring trends.
About Upstream Bio’s Workforce
Upstream Bio, Inc. (UPB) is a Biotech and Healthcare Services company that employs 77 people worldwide as of March 2026. It is the 5th-largest by headcount among its peers. Founded in 2021, the company is headquartered in Waltham, Massachusetts and trades on the NASDAQ.
Upstream Bio's workforce has grown 124.4% from 2023 to 2026, up 4.0% year over year in 2026. Its workforce is concentrated most in North America (97.7%), followed by Eastern Europe (2.3%).
Upstream Bio's functional groups are Finance and Operations (52.4%), Sales and Marketing (34.6%), and Engineering (13.0%), with Finance and Operations growing fastest (up 10.4%). The average salary is $174,977, highest in North America at a median of $175,000, down 1.1% year over year in 2026.
Upstream Bio's active job postings fell 40.0% in 2026 to 4, with new postings per month climbing from 0 in 2023 to 4 in 2026.
Sourced from Revelio Labs workforce data.
- Ticker
- NASDAQ: UPB
- Headquarters
- Waltham, Massachusetts
- Founded
- 2021
- Industry
- Biotech and Healthcare Services
- Employees
- 77
- YoY
- +4.0% (+18)
As of March 2026
Upstream Bio workforce metrics
Unlock hiring rate, attrition rate, and 12 additional workforce metrics for Upstream Bio. Compare to peers, export the dataset, and access the full quarterly history.
Unlock MetricsUpstream Bio Annual Employee Count (2023-2026)
- Upstream Bio had 77 employees in 2026, a 4.0% increase (+18) from 2025.
- Upstream Bio had 75 employees in 2025, a 7.1% increase (+23) from 2024.
- Upstream Bio had 52 employees in 2024, a 15.9% increase (+17) from 2023.
- Upstream Bio had 35 employees in 2023, a 0.5% decline (+4) from 2022.
Upstream Bio's total workforce has grown from 34 employees in 2023 to 77 in 2026.
Upstream Bio, Inc. quarterly employee count
| Year | Qtr | Employees | YoY Change | YoY % |
|---|---|---|---|---|
| 2026 | Q1 | 77 | +18 | +4.0% |
| 2025 | Q4 | 75 | +23 | +7.1% |
| 2025 | Q3 | 69 | +25 | +8.1% |
| 2025 | Q2 | 69 | +25 | +16.1% |
| 2025 | Q1 | 59 | +18 | +12.8% |
| 2024 | Q4 | 52 | +17 | +15.9% |
| 2024 | Q3 | 44 | +7 | +11.6% |
| 2024 | Q2 | 44 | +10 | +8.2% |
| 2024 | Q1 | 41 | +4 | +5.4% |
| 2023 | Q4 | 35 | +4 | -0.5% |
| 2023 | Q3 | 37 | +13 | +6.9% |
| 2023 | Q2 | 34 | +14 | -0.5% |
See Upstream Bio's complete headcount history, including quarterly breakdowns.
Get the DataUpstream Bio Employee Count by Region (2026)
North America accounts for the largest share of Upstream Bio's global workforce with approximately 98% of total employees, followed by Eastern Europe.
Upstream Bio employees by region
| Region | Employees | % of Total |
|---|---|---|
| North America | 74 | 97.7% |
| Eastern Europe | 2 | 2.3% |
Drill into city-level data, hiring trends by region, and historic geographic shifts.
Unlock Geographic DataUpstream Bio Employee Count by Department (2026)
Upstream Bio's employee groups are Finance and Operations (52.4%), Sales and Marketing (34.6%), and Engineering (13.0%).
Upstream Bio employees by department
| Department | Employees | % of Total |
|---|---|---|
| Finance and Operations | 40 | 52.4% |
| Sales and Marketing | 27 | 34.6% |
| Engineering | 10 | 13.0% |
Compare Upstream Bio's department mix to industry peers.
See Full DataUpstream Bio Employee Salary by Region (2026)
Upstream Bio's average employee salary is $174,977 globally. Employees in North America receive the highest compensation.
Upstream Bio median employee salary by region (USD)
| Region | Median Salary |
|---|---|
| North America | $175,000 |
Unlock salary by role, level, and city — and compare to Upstream Bio's industry peers.
Unlock Salary DataUpstream Bio Job Openings and Hiring Trends (2023-2026)
- Upstream Bio had 4 active job postings in 2026, a 40.0% decline (-2) from 2025.
- Upstream Bio had 6 active job postings in 2025, a 40.0% decline (-3) from 2024.
- Upstream Bio had 9 active job postings in 2024, a 160.0% increase (+8) from 2023.
- Upstream Bio had 1 active job postings in 2023, a 150.0% decline from 2022.
- Hiring velocity in 2026: 4 new roles/month, up from 4 in 2025 and 2 in 2024.
Upstream Bio's active job postings fell 40.0% in 2026 to 4, with new postings per month climbing from 0 in 2023 to 4 in 2026.
Track new postings per month, role-level demand, and hiring velocity vs. peers.
Unlock Hiring DataSimilar Companies
Similar Biotech and Healthcare Services Companies by Employee Count
Frequently Asked Questions About Upstream Bio
- How fast is Upstream Bio growing?
- In 2026, Upstream Bio's headcount grew 4.0% to 77 employees, up from 59 in 2025.
- See the full headcount history
- Where are Upstream Bio employees located?
- Most Upstream Bio employees are based in North America (97.7% of headcount), followed by Eastern Europe.
- Explore where the workforce is based
- What is the average salary at Upstream Bio?
- The average employee salary at Upstream Bio is approximately $175k per year.
- Analyze the salary distribution
- How many new job postings does Upstream Bio open per year?
- In Q1 2026, Upstream Bio opened 11 new job postings. In 2025, Upstream Bio opened 42 new job postings — about 4 per month.
- Track hiring trends by role
- When was Upstream Bio founded and where is it headquartered?
- Upstream Bio was founded in 2021 and is headquartered in Waltham, Massachusetts.
- Compare Upstream Bio to industry peers
Speak with a workforce expert about Upstream Bio.
Book a DemoSee something that doesn't look right? Reach out and our team will review it.