How many employees work at Spero Therapeutics?
Spero Therapeutics, Inc. (SPRO) has approximately 24 total employees worldwide as of March 2026, according to Revelio Labs workforce intelligence data. Spero Therapeutics’s total headcount has declined 43.5% from 42 employees in 2023 to 24 in 2026.
Is Spero Therapeutics hiring right now?
No, Spero Therapeutics is not actively hiring. Spero Therapeutics had 0 active job postings in 2026, a 0.0% no change from 2025 — see job openings & hiring trends.
About Spero Therapeutics’s Workforce
Spero Therapeutics, Inc. (SPRO) is a Pharmaceuticals company that employs 24 people worldwide as of March 2026. It is the 9th-largest by headcount among its peers. Founded in 2013, the company is headquartered in Cambridge, Massachusetts and trades on the NASDAQ.
Spero Therapeutics's workforce has declined 43.5% from 2023 to 2026, down 2.4% year over year in 2026. It fell to a low of 24 in 2026 Q1 before recovering. Its workforce is concentrated most in North America (88.8%), followed by Arab States (5.9%) and North Africa (3.1%).
Spero Therapeutics's functional groups are Finance and Operations (57.8%), Sales and Marketing (25.8%), and Engineering (16.4%). The average salary is $205,666, highest in North America at a median of $222,000, down 8.4% year over year in 2026.
Spero Therapeutics's hiring activity held steady in 2026. Overall employee sentiment is positive and improving.
Sourced from Revelio Labs workforce data.
- Ticker
- NASDAQ: SPRO
- Headquarters
- Cambridge, Massachusetts
- Founded
- 2013
- Industry
- Pharmaceuticals
- Employees
- 24
- YoY
- -2.4% (-3)
As of March 2026
Spero Therapeutics workforce metrics
Unlock hiring rate, attrition rate, and 12 additional workforce metrics for Spero Therapeutics. Compare to peers, export the dataset, and access the full quarterly history.
Unlock MetricsSpero Therapeutics Annual Employee Count (2023-2026)
- Spero Therapeutics had 24 employees in 2026, a 2.4% decline (-3) from 2025.
- Spero Therapeutics had 25 employees in 2025, a 9.0% decline (-4) from 2024.
- Spero Therapeutics had 29 employees in 2024, a 17.5% decline (-10) from 2023.
- Spero Therapeutics had 39 employees in 2023, a 4.5% decline (+2) from 2022.
Spero Therapeutics's total workforce has declined from 42 employees in 2023 to 24 in 2026.
Spero Therapeutics, Inc. quarterly employee count
| Year | Qtr | Employees | YoY Change | YoY % |
|---|---|---|---|---|
| 2026 | Q1 | 24 | -3 | -2.4% |
| 2025 | Q4 | 25 | -4 | -9.0% |
| 2025 | Q3 | 27 | -11 | -18.0% |
| 2025 | Q2 | 26 | -13 | -20.0% |
| 2025 | Q1 | 27 | -13 | -24.1% |
| 2024 | Q4 | 29 | -10 | -17.5% |
| 2024 | Q3 | 38 | -1 | -3.7% |
| 2024 | Q2 | 39 | -3 | -6.2% |
| 2024 | Q1 | 40 | +0 | -1.4% |
| 2023 | Q4 | 39 | +2 | -4.5% |
| 2023 | Q3 | 39 | +5 | +3.9% |
| 2023 | Q2 | 42 | +4 | +5.1% |
See Spero Therapeutics's complete headcount history, including quarterly breakdowns.
Get the DataSpero Therapeutics Employee Count by Region (2026)
North America accounts for the largest share of Spero Therapeutics's global workforce with approximately 89% of total employees, followed by Arab States and North Africa.
Spero Therapeutics employees by region
| Region | Employees | % of Total |
|---|---|---|
| North America | 21 | 88.8% |
| Arab States | 1 | 5.9% |
| North Africa | 1 | 3.1% |
| Southeast Asia | 1 | 2.2% |
Drill into city-level data, hiring trends by region, and historic geographic shifts.
Unlock Geographic DataSpero Therapeutics Employee Count by Department (2026)
Spero Therapeutics's employee groups are Finance and Operations (57.8%), Sales and Marketing (25.8%), and Engineering (16.4%).
Spero Therapeutics employees by department
| Department | Employees | % of Total |
|---|---|---|
| Finance and Operations | 14 | 57.8% |
| Sales and Marketing | 6 | 25.8% |
| Engineering | 4 | 16.4% |
Compare Spero Therapeutics's department mix to industry peers.
See Full DataSpero Therapeutics Employee Salary by Region (2026)
Spero Therapeutics's average employee salary is $205,666 globally. Employees in North America receive the highest compensation.
Spero Therapeutics median employee salary by region (USD)
| Region | Median Salary |
|---|---|
| North America | $222,000 |
Unlock salary by role, level, and city — and compare to Spero Therapeutics's industry peers.
Unlock Salary DataSpero Therapeutics Job Openings and Hiring Trends (2023-2026)
- Spero Therapeutics had 0 active job postings in 2026, a 0% no change from 2025.
- Spero Therapeutics had 0 active job postings in 2025, a 0% no change from 2024.
- Spero Therapeutics had 0 active job postings in 2024, a 200.0% decline (-2) from 2023.
- Spero Therapeutics had 2 active job postings in 2023, a 138.5% decline from 2022.
- Hiring velocity in 2026: 0 new roles/month, up from 0 in 2025 and 0 in 2024.
Spero Therapeutics's hiring activity held steady in 2026.
Track new postings per month, role-level demand, and hiring velocity vs. peers.
Unlock Hiring DataSpero Therapeutics Employee Sentiment (2026)
Revelio Labs tracks employee sentiment across Spero Therapeutics's workforce based on public professional data. Overall sentiment is positive and has improved year over year in 2026.
Overall
Unlock the full sentiment breakdown by department, tenure, and trend over time.
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Frequently Asked Questions About Spero Therapeutics
- How fast is Spero Therapeutics growing?
- In 2026, Spero Therapeutics's headcount shrank 2.4% to 24 employees, down from 27 in 2025.
- See the full headcount history
- Where are Spero Therapeutics employees located?
- Most Spero Therapeutics employees are based in North America (88.8% of headcount), followed by Arab States and North Africa.
- Explore where the workforce is based
- What is the average salary at Spero Therapeutics?
- The average employee salary at Spero Therapeutics is approximately $205.7k per year.
- Analyze the salary distribution
- How many new job postings does Spero Therapeutics open per year?
- In Q1 2026, Spero Therapeutics opened 0 new job postings. In 2025, Spero Therapeutics opened 1 new job postings — about 0 per month.
- Track hiring trends by role
- When was Spero Therapeutics founded and where is it headquartered?
- Spero Therapeutics was founded in 2013 and is headquartered in Cambridge, Massachusetts.
- Compare Spero Therapeutics to industry peers
Speak with a workforce expert about Spero Therapeutics.
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