How many employees work at Denali Therapeutics?
Denali Therapeutics, Inc. (DNLI) has approximately 515 total employees worldwide as of March 2026, according to Revelio Labs workforce intelligence data. Denali Therapeutics’s total headcount has grown 15.2% from 447 employees in 2023 to 515 in 2026.
Is Denali Therapeutics hiring right now?
Yes, Denali Therapeutics is actively hiring. Denali Therapeutics had 38 active job postings in 2026, a 40.0% decline from 2025 — see job openings & hiring trends.
About Denali Therapeutics’s Workforce
Denali Therapeutics, Inc. (DNLI) is a Pharmaceuticals company that employs 515 people worldwide as of March 2026. It is the 6th-largest by headcount among its peers. Founded in 2013, the company is headquartered in San Francisco, California and trades on the NASDAQ.
Denali Therapeutics's workforce has grown 15.2% from 2023 to 2026, up 0.6% year over year in 2026. It fell to a low of 385 in 2024 Q2 before recovering. Its workforce is concentrated most in North America (95.7%), followed by Western Europe (3.0%) and Northern Europe (0.4%).
Denali Therapeutics's functional groups are Finance and Operations (42.8%), Engineering (36.5%), and Sales and Marketing (20.6%), with Engineering growing fastest (up 1.7%). The average salary is $194,741, ranging from a median of $268,000 in Western Europe to $172,000 in North America, up 2.8% year over year in 2026.
Denali Therapeutics's active job postings fell 40.0% in 2026 to 38, with new postings per month cooling from 26 in 2023 to 16 in 2026. Overall employee sentiment is neutral but declining.
Sourced from Revelio Labs workforce data.
- Ticker
- NASDAQ: DNLI
- Headquarters
- San Francisco, California
- Founded
- 2013
- Industry
- Pharmaceuticals
- Employees
- 515
- YoY
- +0.6% (+56)
As of March 2026
Denali Therapeutics workforce metrics
Unlock hiring rate, attrition rate, and 12 additional workforce metrics for Denali Therapeutics. Compare to peers, export the dataset, and access the full quarterly history.
Unlock MetricsDenali Therapeutics Annual Employee Count (2023-2026)
- Denali Therapeutics had 515 employees in 2026, a 0.6% increase (+56) from 2025.
- Denali Therapeutics had 505 employees in 2025, a 1.3% increase (+73) from 2024.
- Denali Therapeutics had 432 employees in 2024, a 2.3% decline (-8) from 2023.
- Denali Therapeutics had 440 employees in 2023, a 0.8% decline (+5) from 2022.
Denali Therapeutics's total workforce has grown from 447 employees in 2023 to 515 in 2026.
Denali Therapeutics, Inc. quarterly employee count
| Year | Qtr | Employees | YoY Change | YoY % |
|---|---|---|---|---|
| 2026 | Q1 | 515 | +56 | +0.6% |
| 2025 | Q4 | 505 | +73 | +1.3% |
| 2025 | Q3 | 511 | +101 | +5.6% |
| 2025 | Q2 | 504 | +119 | +7.7% |
| 2025 | Q1 | 459 | +67 | +4.3% |
| 2024 | Q4 | 432 | -8 | -2.3% |
| 2024 | Q3 | 410 | -32 | -7.0% |
| 2024 | Q2 | 385 | -62 | -9.3% |
| 2024 | Q1 | 392 | -47 | -5.7% |
| 2023 | Q4 | 440 | +5 | -0.8% |
| 2023 | Q3 | 442 | +16 | +0.9% |
| 2023 | Q2 | 447 | +31 | +1.8% |
See Denali Therapeutics's complete headcount history, including quarterly breakdowns.
Get the DataDenali Therapeutics Employee Count by Region (2026)
North America accounts for the largest share of Denali Therapeutics's global workforce with approximately 96% of total employees, followed by Western Europe and Northern Europe.
Denali Therapeutics employees by region
| Region | Employees | % of Total |
|---|---|---|
| North America | 476 | 95.7% |
| Western Europe | 15 | 3.0% |
| Northern Europe | 2 | 0.4% |
| South Asia | 2 | 0.4% |
| South America | 1 | 0.2% |
| Southern Europe | 1 | 0.1% |
| Central and Western Asia | 0 | 0.0% |
Drill into city-level data, hiring trends by region, and historic geographic shifts.
Unlock Geographic DataDenali Therapeutics Employee Count by Department (2026)
Denali Therapeutics's employee groups are Finance and Operations (42.8%), Engineering (36.5%), and Sales and Marketing (20.6%).
Denali Therapeutics employees by department
| Department | Employees | % of Total |
|---|---|---|
| Finance and Operations | 221 | 42.8% |
| Engineering | 188 | 36.5% |
| Sales and Marketing | 106 | 20.6% |
Compare Denali Therapeutics's department mix to industry peers.
See Full DataDenali Therapeutics Employee Salary by Region (2026)
Denali Therapeutics's average employee salary is $194,741 globally. Employees in Western Europe receive the highest compensation, with median pay approximately 1.4x the global average. Pay is lowest in North America, at a median of $172,000.
Denali Therapeutics median employee salary by region (USD)
| Region | Median Salary |
|---|---|
| Western Europe | $268,000 |
| North America | $172,000 |
Unlock salary by role, level, and city — and compare to Denali Therapeutics's industry peers.
Unlock Salary DataDenali Therapeutics Job Openings and Hiring Trends (2023-2026)
- Denali Therapeutics had 38 active job postings in 2026, a 40.0% decline (+13) from 2025.
- Denali Therapeutics had 25 active job postings in 2025, a 64.9% decline (-24) from 2024.
- Denali Therapeutics had 49 active job postings in 2024, a 48.1% increase (+19) from 2023.
- Denali Therapeutics had 30 active job postings in 2023, a 82.4% decline from 2022.
- Hiring velocity in 2026: 16 new roles/month, up from 15 in 2025 and 18 in 2024.
Denali Therapeutics's hiring is slowing: active job postings fell 40.0% in 2026 to 38, with new postings per month cooling from 26 in 2023 to 16 in 2026.
Track new postings per month, role-level demand, and hiring velocity vs. peers.
Unlock Hiring DataDenali Therapeutics Employee Sentiment (2026)
Revelio Labs tracks employee sentiment across Denali Therapeutics's workforce based on public professional data. Overall sentiment is neutral and has declined year over year in 2026.
Overall
Unlock the full sentiment breakdown by department, tenure, and trend over time.
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Frequently Asked Questions About Denali Therapeutics
- How fast is Denali Therapeutics growing?
- In 2026, Denali Therapeutics's headcount grew 0.6% to 515 employees, up from 459 in 2025.
- See the full headcount history
- Where are Denali Therapeutics employees located?
- Most Denali Therapeutics employees are based in North America (95.7% of headcount), followed by Western Europe and Northern Europe.
- Explore where the workforce is based
- What is the average salary at Denali Therapeutics?
- The average employee salary at Denali Therapeutics is approximately $194.7k per year.
- Analyze the salary distribution
- How many new job postings does Denali Therapeutics open per year?
- In Q1 2026, Denali Therapeutics opened 48 new job postings. In 2025, Denali Therapeutics opened 185 new job postings — about 15 per month.
- Track hiring trends by role
- When was Denali Therapeutics founded and where is it headquartered?
- Denali Therapeutics was founded in 2013 and is headquartered in San Francisco, California.
- Compare Denali Therapeutics to industry peers
Speak with a workforce expert about Denali Therapeutics.
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