How many employees work at Spyre Therapeutics?
Spyre Therapeutics, Inc. (SYRE) has approximately 108 total employees worldwide as of March 2026, according to Revelio Labs workforce intelligence data. Spyre Therapeutics’s total headcount has grown 218.7% from 34 employees in 2023 to 108 in 2026.
Is Spyre Therapeutics hiring right now?
Yes, Spyre Therapeutics is actively hiring. Spyre Therapeutics had 10 active job postings in 2026, a 66.7% decline from 2025 — see job openings & hiring trends.
About Spyre Therapeutics’s Workforce
Spyre Therapeutics, Inc. (SYRE) is a Pharmaceuticals company that employs 108 people worldwide as of March 2026. It is the 8th-largest by headcount among its peers. Founded in 2013, the company is headquartered in Waltham, Massachusetts and trades on the NASDAQ.
Spyre Therapeutics's workforce has grown 218.7% from 2023 to 2026, up 1.8% year over year in 2026. Its workforce is concentrated most in North America (97.2%), followed by Western Europe (1.8%) and Northern Europe (0.9%).
Spyre Therapeutics's functional groups are Finance and Operations (57.1%), Sales and Marketing (23.9%), and Engineering (19.0%), with Sales and Marketing growing fastest (up 23.3%). The average salary is $214,469, highest in North America at a median of $208,000, down 2.3% year over year in 2026.
Spyre Therapeutics's active job postings fell 66.7% in 2026 to 10, with new postings per month climbing from 2 in 2023 to 11 in 2026. Overall employee sentiment is neutral but declining.
Sourced from Revelio Labs workforce data.
- Ticker
- NASDAQ: SYRE
- Headquarters
- Waltham, Massachusetts
- Founded
- 2013
- Industry
- Pharmaceuticals
- Employees
- 108
- YoY
- +1.8% (+29)
As of March 2026
Spyre Therapeutics workforce metrics
Unlock hiring rate, attrition rate, and 12 additional workforce metrics for Spyre Therapeutics. Compare to peers, export the dataset, and access the full quarterly history.
Unlock MetricsSpyre Therapeutics Annual Employee Count (2023-2026)
- Spyre Therapeutics had 108 employees in 2026, a 1.8% increase (+29) from 2025.
- Spyre Therapeutics had 101 employees in 2025, a 8.8% increase (+28) from 2024.
- Spyre Therapeutics had 73 employees in 2024, a 9.3% increase (+31) from 2023.
- Spyre Therapeutics had 42 employees in 2023, a 54.4% decline (-24) from 2022.
Spyre Therapeutics's total workforce has grown from 34 employees in 2023 to 108 in 2026.
Spyre Therapeutics, Inc. quarterly employee count
| Year | Qtr | Employees | YoY Change | YoY % |
|---|---|---|---|---|
| 2026 | Q1 | 108 | +29 | +1.8% |
| 2025 | Q4 | 101 | +28 | +8.8% |
| 2025 | Q3 | 95 | +28 | +11.9% |
| 2025 | Q2 | 89 | +29 | +11.6% |
| 2025 | Q1 | 79 | +29 | +14.9% |
| 2024 | Q4 | 73 | +31 | +9.3% |
| 2024 | Q3 | 67 | +31 | +7.0% |
| 2024 | Q2 | 60 | +26 | +0.8% |
| 2024 | Q1 | 50 | -12 | -44.0% |
| 2023 | Q4 | 42 | -24 | -54.4% |
| 2023 | Q3 | 36 | -32 | -58.0% |
| 2023 | Q2 | 34 | -47 | -55.2% |
See Spyre Therapeutics's complete headcount history, including quarterly breakdowns.
Get the DataSpyre Therapeutics Employee Count by Region (2026)
North America accounts for the largest share of Spyre Therapeutics's global workforce with approximately 97% of total employees, followed by Western Europe and Northern Europe.
Spyre Therapeutics employees by region
| Region | Employees | % of Total |
|---|---|---|
| North America | 98 | 97.2% |
| Western Europe | 2 | 1.8% |
| Northern Europe | 1 | 0.9% |
| South America | 0 | 0.1% |
Drill into city-level data, hiring trends by region, and historic geographic shifts.
Unlock Geographic DataSpyre Therapeutics Employee Count by Department (2026)
Spyre Therapeutics's employee groups are Finance and Operations (57.1%), Sales and Marketing (23.9%), and Engineering (19.0%).
Spyre Therapeutics employees by department
| Department | Employees | % of Total |
|---|---|---|
| Finance and Operations | 62 | 57.1% |
| Sales and Marketing | 26 | 23.9% |
| Engineering | 21 | 19.0% |
Compare Spyre Therapeutics's department mix to industry peers.
See Full DataSpyre Therapeutics Employee Salary by Region (2026)
Spyre Therapeutics's average employee salary is $214,469 globally. Employees in North America receive the highest compensation.
Spyre Therapeutics median employee salary by region (USD)
| Region | Median Salary |
|---|---|
| North America | $208,000 |
Unlock salary by role, level, and city — and compare to Spyre Therapeutics's industry peers.
Unlock Salary DataSpyre Therapeutics Job Openings and Hiring Trends (2023-2026)
- Spyre Therapeutics had 10 active job postings in 2026, a 66.7% decline (-3) from 2025.
- Spyre Therapeutics had 13 active job postings in 2025, a 26.7% decline (-4) from 2024.
- Spyre Therapeutics had 17 active job postings in 2024, a 177.8% increase (+16) from 2023.
- Spyre Therapeutics had 1 active job postings in 2023, a 200.0% increase from 2022.
- Hiring velocity in 2026: 11 new roles/month, up from 11 in 2025 and 12 in 2024.
Spyre Therapeutics's active job postings fell 66.7% in 2026 to 10, with new postings per month climbing from 2 in 2023 to 11 in 2026.
Track new postings per month, role-level demand, and hiring velocity vs. peers.
Unlock Hiring DataSpyre Therapeutics Employee Sentiment (2026)
Revelio Labs tracks employee sentiment across Spyre Therapeutics's workforce based on public professional data. Overall sentiment is neutral and has declined year over year in 2026.
Overall
Unlock the full sentiment breakdown by department, tenure, and trend over time.
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Frequently Asked Questions About Spyre Therapeutics
- How fast is Spyre Therapeutics growing?
- In 2026, Spyre Therapeutics's headcount grew 1.8% to 108 employees, up from 79 in 2025.
- See the full headcount history
- Where are Spyre Therapeutics employees located?
- Most Spyre Therapeutics employees are based in North America (97.2% of headcount), followed by Western Europe and Northern Europe.
- Explore where the workforce is based
- What is the average salary at Spyre Therapeutics?
- The average employee salary at Spyre Therapeutics is approximately $214.5k per year.
- Analyze the salary distribution
- How many new job postings does Spyre Therapeutics open per year?
- In Q1 2026, Spyre Therapeutics opened 33 new job postings. In 2025, Spyre Therapeutics opened 136 new job postings — about 11 per month.
- Track hiring trends by role
- When was Spyre Therapeutics founded and where is it headquartered?
- Spyre Therapeutics was founded in 2013 and is headquartered in Waltham, Massachusetts.
- Compare Spyre Therapeutics to industry peers
Speak with a workforce expert about Spyre Therapeutics.
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