How many employees work at Castle Biosciences?

Castle Biosciences, Inc. has 791 employees, according to Revelio Labs workforce intelligence data. The YoY growth rate is 13.0%.

Data source: Revelio Labs Coverage: Global workforce Latest update: December 2025

About Castle Biosciences

Castle Biosciences (Nasdaq: CSTL) is a leading diagnostics company focused on transforming disease management by keeping people first—the patients who benefit from the information that our advanced diagnostic tests provide, the clinicians who use our tests to guide disease management decisions, our talented and valued employees, and our investors. Our innovative portfolio of commercial and pipeline tests targets unmet clinical need along the patient care continuum. We currently market six proprietary tests designed to answer clinical questions and address treatment plan challenges facing physicians in dermatologic cancers, uveal melanoma, Barrett’s esophagus, and mental health. https://castletestinfo.com Our test for invasive cutaneous melanoma, DecisionDx®-Melanoma, is a proprietary gene expression profile (GEP) test that uses an individual patient’s tumor biology to predict the risk of metastasis or recurrence, as well as the risk of sentinel lymph node positivity, independent of traditional staging factors. http://bit.ly/DDx-Melanoma DecisionDx®-SCC is our GEP test that predicts the risk of metastasis in patients with cutaneous squamous cell carcinoma, who have one or more risk factors. https://bit.ly/DDx-SCC DecisionDx®-UM, the standard of care in uveal melanoma staging, is our GEP test that predicts the risk of metastasis for patients with uveal melanoma, a rare eye cancer. https://bit.ly/DDx-UM Our comprehensive diagnostic offering — myPath® Melanoma and DiffDx®-Melanoma — provides a highly accurate, objective result to aid dermatopathologists and dermatologists in characterizing suspicious pigmented lesions. https://bit.ly/myPathDiffDx TissueCypher® Barrett’s Esophagus is the world’s first precision medicine test designed to predict future development of esophageal cancer in patients with Barrett’s esophagus. https://tissuecypher.com Castle Biosciences is based in Friendswood, TX and has laboratory operations in Phoenix, AZ, and Pittsburgh, PA.

As of December 2025

Castle Biosciences
workforce metrics

Headcount

791

Avg. Salary

$117.2k

Tenure

2.4yr

Growth Rate

13.0%

Hiring Rate

Attrition Rate

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Employee Headcount

Interactive chart of Castle Biosciences annual worldwide employee count from 2023 to 2025.

  • Castle Biosciences total number of employees in 2025 was 793, a 13.0% increase from 2024.
  • Castle Biosciences total number of employees in 2024 was 696, a 14.2% increase from 2023.
  • Castle Biosciences total number of employees in 2023 was 603, a 7.8% increase from 2022.

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Employee Geographic Breakdown

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Employee Role Breakdown

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Employee Compensation

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Active Job Postings

Interactive chart of Castle Biosciences annual active job postings from 2023 to 2025.

  • Castle Biosciences active job postings in 2025 was 17, a 11.1% decline from 2024.
  • Castle Biosciences active job postings in 2024 was 19, a 92.3% increase from 2023.
  • Castle Biosciences active job postings in 2023 was 7, a 35.3% decline from 2022.

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Employee Sentiment

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